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Topical formulations were subsequently developed and approved for hair loss use: first for men (1988) and later for women (1991)

They are typically released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and NLRPs (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing, also known as NOD-like receptors)

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By binding to fibroblast receptors, the copper tripeptide enhances the production of structural proteins and accelerates the skins reparative response